A new approach to reduce abdominal fat has been shown to be promising in animal testing. It combines drugs known to turn white fats storing energy into brown fat that gives energy, but in local form.
A new patch transforms white static fat into brown fat, which can be burned. It presents a new way of delivering drugs, via a micro-needle patch.
This innovative approach developed by scientists at the Singapore Technological University reduced weight gain in mice by more than 30% over four weeks. The new type of skin patch contains hundreds of micro-needles, each finer than a human hair, which are loaded with beta-3 adrenergic receptor agonist or T3 triiodothyronine thyroid hormone.
From the mouse to the man
With the micro-needles embedded in the skin of the mice, the surrounding fats started to brown in five days, which helped to increase energy expenditure. The treated mice also had significantly lower blood cholesterol and fatty acid levels than the untreated mice. The advantage is that the products are delivered only locally because they are a source of complication in general.
"What we are trying to develop is a painless, unobtrusive, affordable and usable patch," says Professor Chen, an obesity expert. These data could encourage Phase I clinical studies in humans in the hope that these micro-needle patches can become an effective and cost-effective modality for the prevention or treatment of obesity.
The team estimates that its prototype patch has a hardware cost of about US $ 3.50.